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Cytokine profile in chronic cardiac failure
I C Steele1, A M Nugent, S Maguire
1Department of Medicine, Royal Victoria Hospital, Belfast, UK.
European Journal of Clinical Investigation
|November 1, 1996
Summary
Tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) show elevated levels in chronic cardiac failure (CCF). Measuring TNF receptor p55 and IL-6 may improve detection of cytokine activity in CCF patients.
Area of Science:
- Cardiology
- Immunology
- Biochemistry
Background:
- Elevated tumor necrosis factor alpha (TNF-alpha) is linked to chronic cardiac failure (CCF) severity and cachexia.
- Cytokine activation is implicated in the pathophysiology of CCF.
- Improved detection methods for cytokine activity are needed in CCF research.
Purpose of the Study:
- To assess TNF receptor p55 and interleukin-6 (IL-6) levels in patients with CCF.
- To investigate the relationship between inflammatory markers and CCF.
- To enhance the detection rate of TNF-alpha activation in CCF.
Main Methods:
- Measured TNF-alpha, TNF receptor p55, IL-6, IL-8, and C-reactive protein in 34 CCF patients and 24 controls.
- Utilized median and range for reporting biomarker concentrations.
- Statistical analysis included P-values to determine significance (P < 0.05).
Main Results:
- TNF receptor p55 and IL-6 were significantly elevated in CCF patients compared to controls.
- No significant correlation was found between inflammatory markers and clinical CCF parameters.
- Inflammatory markers were more frequently elevated in the CCF group overall.
Conclusions:
- TNF receptor p55 and IL-6 are elevated in CCF, suggesting their involvement.
- The precise reasons for elevated inflammatory markers in CCF remain unclear.
- Future studies should include TNF receptor p55 and IL-6 for comprehensive cytokine activity assessment in CCF.