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Posttransplant malaria

A Türkmen1, M S Sever, T Ecder

  • 1Department of Infectious Diseases, University of Istanbul, Istanbul School of Medicine, Turkey.

Transplantation
|November 27, 1996
PubMed
Summary

Malaria is a frequent complication in renal transplant recipients from high-risk areas. Early diagnosis and treatment of Plasmodium infection are crucial for improving outcomes in these vulnerable patients.

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • Renal transplant recipients are at increased risk for infections due to immunosuppression.
  • Malaria, caused by Plasmodium parasites, poses a significant threat in post-transplant settings.

Purpose of the Study:

  • To determine the frequency and clinical features of Plasmodium infection in renal transplant recipients.
  • To evaluate the outcomes of antimalarial treatment in this patient population.

Main Methods:

  • Retrospective analysis of 420 renal transplant recipients.
  • Diagnosis of Plasmodium infection through blood film examination.
  • Treatment with chloroquine phosphate, with or without primaquine phosphate.

Main Results:

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  • Plasmodium infection was diagnosed in 2.6% of patients (11/420).
  • Most infections occurred in patients transplanted in India.
  • Successful treatment with antimalarials in 10 out of 11 patients; one patient developed severe hemolysis and acute renal failure.

Conclusions:

  • Malaria is a notable infection in renal transplant recipients, particularly those with donors from malaria-endemic regions.
  • Vigilance for malaria in transplant recipients is essential for early detection and management.
  • Prompt diagnosis and treatment can improve prognosis and prevent severe complications.