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Expression of tissue factor in glioma
Noshuyo Byori = Brain Tumor Pathology
|November 1, 1996
Summary
Tissue factor (TF) is expressed in gliomas and its expression level correlates with malignancy grade. This suggests TF may play a role in glioma cell growth beyond hemostasis.
Area of Science:
- Neuroscience
- Oncology
- Molecular Biology
Background:
- Tissue factor (TF) is a glycoprotein initiating coagulation, also found in tumor cells.
- TF's role in the interferon receptor family and as an immediate early gene suggests functions beyond hemostasis.
- Its expression in tumor cells warrants investigation in neurological cancers like gliomas.
Purpose of the Study:
- To investigate the expression of Tissue Factor (TF) in various types of gliomas.
- To determine if TF expression levels correlate with glioma malignancy grade.
Main Methods:
- Immunocytochemistry was used to detect TF expression in 3 glioma cell lines.
- Immunohistochemical analysis was performed on 44 surgical glioma specimens.
Main Results:
- TF was expressed in all investigated gliomas.
- TF expression was significantly higher in high-grade gliomas (glioblastomas and anaplastic astrocytomas) compared to benign gliomas.
- 95% of glioblastomas and 86% of anaplastic astrocytomas showed moderate to strong TF positivity.
Conclusions:
- Tissue Factor is expressed in gliomas.
- TF expression levels correlate positively with glioma malignancy.
- TF may be involved in glioma cell proliferation and progression.