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Published on: December 15, 2011
[Hypergammaglobulinemia D and familial urticaria in children]
B Bader-Meunier1, P Y Venencie, A Vieillefond
1Service de Pédiatrie générale, Hôpital Bicêtre, Le Kremlin Bicêtre.
Objective:
Recall the main elements suggesting the diagnosis of hyperimmunoglobulinemia D based on a family case of chronic urticaria.
Case Report:
A boy and his mother presented the same signs of urticaria, fever and joint pain. Laboratory results showed an inflammatory syndrome in both. In the child, the first manifestations occurred during the age of one year. Hyperimmunoglobulinemia D was confirmed by persistently high serum levels.
Conclusion:
The diagnosis of hyperimmunoglobuliemia D can be entertained in a child in a family with chronic urticaria. Fever, joint pain, digestive disorders and enlarged lymph nodes are suggestive and the diagnosis is confirmed by a clear elevation of serum IgD.
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