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First trimester chorionic villus sampling in twin gestations

L De Catte1, I Liebaers, W Foulon

  • 1Department of Obstetrics and Gynecology, Akademisch Ziekenhuis Vrije Universiteit Brussel, Belgium.

American Journal of Perinatology
|October 1, 1996
PubMed
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First-trimester chorionic villus sampling (CVS) offers accurate prenatal diagnosis for twin pregnancies. While risks are comparable to non-diagnosed twins, a transcervical approach for both fetuses is not advised.

Area of Science:

  • Maternal-fetal medicine
  • Prenatal diagnostics
  • Reproductive genetics

Background:

  • Advanced maternal age and novel fertilization techniques necessitate reliable first-trimester prenatal diagnosis.
  • Twin pregnancies present unique challenges for prenatal assessment and genetic evaluation.
  • Chorionic villus sampling (CVS) is a key first-trimester invasive diagnostic procedure.

Purpose of the Study:

  • To evaluate the accuracy and safety of first-trimester chorionic villus sampling (CVS) in twin gestations.
  • To assess the pregnancy outcomes associated with CVS in twin pregnancies.
  • To compare CVS outcomes in twins with a control group of non-diagnosed twin pregnancies.

Main Methods:

  • 104 twin pregnancies underwent first-trimester prenatal diagnosis using chorionic villus sampling (CVS).

Related Experiment Videos

  • CVS was performed via transcervical, transabdominal, or combined approaches.
  • Cytogenetic analysis was performed, with follow-up for direct chromosomal abnormalities.

    • Main Results:

    • Cytogenetic results were obtained for all fetuses; four showed abnormalities after further analysis.
    • Two fetal sexing errors occurred with transcervical sampling, highlighting the need for selective sampling.
    • Early fetal loss (3.4%) and perinatal mortality (6.3%) were comparable to a control group (6.9% and 5.3%).

    Conclusions:

    • First-trimester CVS is an accurate and rapid method for prenatal diagnosis in twin pregnancies.
    • Pregnancy outcomes following CVS in twins are acceptable and comparable to non-diagnosed controls.
    • A transcervical sampling approach for both fetuses in twin gestations is not recommended due to potential errors.