[Intensive antibacterial therapy of multiple trauma]

Septic complications are considered among the main causes of death in patients with multiple injuries. In intensive care units their incidence is 33% of all cases. A total of 655 samples of sputum, blood, and urine from 224 patients were examined. The principal agents of septic infections were gram negative aerobic bacilli Pseudomonas aeruginosa and Proteus. The spectrum of activity of penicillins and aminoglycosides has appreciably changed. A decrease of contamination may be attained by arranging a special "cleansing" intensive care unit with continuous exchange of air free of bacteria, a regimen of an operative room, and use of solely cephalosporines combined with fluoroquinolones.