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Fluvoxamine attenuates panic induced by 35% CO2 challenge
H J Pols1, R C Hauzer, J A Meijer
1Department of Psychiatry and Neuropsychology, State University of Limburg, Maastricht, The Netherlands.
The Journal of Clinical Psychiatry
|November 1, 1996
Abstract
Background:
The authors investigated whether 6 weeks of treatment with fluvoxamine would decrease the anxiogenic response to the 35% CO2 challenge in 11 patients with DSM-III-R panic disorder with agoraphobia.
Method:
The patients underwent a 35% CO2 challenge at baseline and again after 6 weeks of fluvoxamine treatment.
Results:
The anxiogenic effect of CO2 was significantly (p < .05) reduced during fluvoxamine treatment.
Conclusion:
The results suggest a relationship between the anxiogenic effect of CO2 and the therapeutic effect of fluvoxamine.