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Potential interaction between warfarin and dicloxacillin

A T Mailloux¹, B E Gidal, C A Sorkness

¹School of Pharmacy, University of Wisconsin, Madison 53706, USA.

The Annals of Pharmacotherapy

|December 1, 1996

Summary

This summary is machine-generated.

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Dicloxacillin may decrease the effectiveness of warfarin, leading to a reduced anticoagulant effect. Patients on warfarin should be closely monitored when starting or stopping dicloxacillin.

Area of Science:

Pharmacology
Drug Interactions
Clinical Medicine

Background:

Warfarin is a common anticoagulant medication.
Dicloxacillin is an antibiotic used to treat bacterial infections.

Observation:

A case study and retrospective review of seven patients showed a decrease in prothrombin time (PT) during concomitant warfarin and dicloxacillin use.
The PT decreased within 4-5 days of starting dicloxacillin, with warfarin concentrations also declining.

Findings:

Concomitant administration of dicloxacillin with warfarin is associated with a reduced anticoagulant effect.
This interaction may be due to decreased systemic warfarin concentrations.
The effect on PT can last up to 3 weeks after discontinuing dicloxacillin.

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Implications:

Clinicians should be aware of this potential interaction and the risk of decreased warfarin anticoagulation.
Close monitoring of international normalized ratios (INRs) and warfarin dosage titration is recommended when initiating or discontinuing dicloxacillin in patients on warfarin.