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Related Experiment Videos

Is endothelin-1 a mediator in asthma?

D W Hay1, P J Henry, R G Goldie

  • 1Department of Pulmonary Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA

American Journal of Respiratory and Critical Care Medicine
|December 1, 1996
PubMed
Summary

Endothelin (ET)-1

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Area of Science:

  • Pulmonary Medicine
  • Pharmacology

Background:

  • Endothelin (ET)-1 is increasingly implicated in asthma pathophysiology.
  • Some evidence suggests ET-1's role, but requires further confirmation.

Purpose of the Study:

  • To critically evaluate the evidence for ET-1 as an asthma mediator.
  • To identify research gaps, particularly regarding ET receptor subtypes and clinical trials.

Main Methods:

  • Review of existing scientific literature on ET-1 and asthma.
  • Analysis of criteria for mediator involvement in disease.

Main Results:

  • Several criteria implicating ET-1 in asthma are met, but data are preliminary.
  • Elucidating ET receptor subtypes mediating ET-1 effects in the lung is crucial.

Conclusions:

  • Definitive proof of ET-1's pathophysiological role in asthma awaits clinical trials of ET receptor antagonists.
  • The role of ET-1 in asthma remains uncertain pending further investigation and clinical data.

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