Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HIV viral dynamics

J M Coffin1

  • 1Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA.

AIDS (London, England)
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

The human immunodeficiency virus (HIV) causes active, steady-state infection with constant viral replication and cell death, even during clinical latency. This understanding shifts the view of HIV pathogenesis and treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.

Science (New York, N.Y.)·2014
Same author

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy.

Nature·2012
Same author

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples.

Advances in virology·2012
Same author

Prevalence of XMRV nucleic acid and antibody in HIV-1-Infected men and in men at risk for HIV-1 Infection.

Advances in virology·2012
Same author

HIV reservoirs and the possibility of a cure for HIV infection.

Journal of internal medicine·2011
Same author

Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2010
Same journal

Clinical implications of the new definition of obesity among persons with HIV.

AIDS (London, England)·2026
Same journal

Cabotegravir and rilpivirine resistance-associated mutations among people with newly diagnosed HIV-1 in the Netherlands.

AIDS (London, England)·2026
Same journal

Pitavastatin effect on enterocyte injury markers in an ART treated HIV population: Insights from REPRIEVE.

AIDS (London, England)·2026
Same journal

Blood pressure control in people with HIV and established atherosclerotic cardiovascular disease: a real-world descriptive analysis.

AIDS (London, England)·2026
Same journal

Genome-wide association study of cardiovascular disease in people with HIV from the Million Veteran Program (MVP).

AIDS (London, England)·2026
Same journal

The US President's Emergency Plan for AIDS Relief-funded service integration protected children from tuberculosis.

AIDS (London, England)·2026
See all related articles

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Recent discoveries reveal rapid turnover of HIV and infected cells in vivo.
  • Antiviral therapy leads to a rapid drop in viral load, challenging previous assumptions.
  • The paradigm of HIV infection has shifted from clinical latency to an active, steady-state model.

Purpose of the Study:

  • To discuss the theoretical basis of the steady-state model of HIV infection.
  • To explore the consequences of this model for understanding HIV pathogenesis.
  • To highlight recent developments and knowledge gaps in HIV research.

Main Methods:

  • Theoretical discussion of the steady-state model.
  • Analysis of factors influencing HIV pathogenesis.

Related Experiment Videos

  • Review of recent developments in HIV research.

    • Main Results:

    • HIV infection is characterized by constant viral replication and cell death, not inactivity during latency.
    • Genetic variation, viral quasispecies, and antiviral resistance are key aspects of HIV evolution.
    • Viral load measurements have significant theoretical and practical implications.

    Conclusions:

    • The steady-state model reframes the understanding of HIV infection and disease progression.
    • Understanding viral dynamics is crucial for controlling HIV pathogenesis.
    • Further research is needed to address significant gaps in our knowledge of HIV infection.