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Related Experiment Videos

Signaling by extracellular nucleotides

A J Brake1, D Julius

  • 1Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143-0450, USA.

Annual Review of Cell and Developmental Biology
|January 1, 1996
PubMed
Summary
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Extracellular adenosine triphosphate (ATP) and nucleotides act as signaling molecules. This review details advances in understanding ATP receptors and their physiological roles.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • Extracellular nucleotides, including adenosine triphosphate (ATP), are released from cells via regulated pathways or membrane damage.
  • These extracellular nucleotides function as crucial intercellular signaling molecules.
  • They mediate a wide range of physiological responses by activating cell surface receptors.

Purpose of the Study:

  • To summarize recent advancements in the molecular characterization of ATP receptors.
  • To discuss the roles of identified ATP receptors in known and emerging physiological processes.

Main Methods:

  • Literature review of recent research on ATP receptors.
  • Analysis of molecular characteristics of ATP receptor subtypes.
  • Synthesis of data on physiological functions mediated by these receptors.

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Main Results:

  • Significant progress has been made in identifying and characterizing various ATP receptor subtypes.
  • Established physiological roles for these receptors have been further elucidated.
  • Novel functions and pathways involving ATP signaling are being uncovered.

Conclusions:

  • The molecular understanding of ATP receptors has advanced significantly.
  • These receptors play critical roles in diverse physiological functions, with new roles continually being identified.
  • Further research into ATP receptor signaling promises to yield new therapeutic targets.