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Dermatofibrosarcoma protuberans

C Garcia1, R E Clark, M Buchanan

  • 1Dermatologic Surgery and Cutaneous Oncology Unit, Duke University Medical Center, Durham, NC 27710, USA.

International Journal of Dermatology
|December 1, 1996
PubMed
Summary
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Dermatofibrosarcoma protuberans (DFSP) is a soft tissue sarcoma treated effectively with Mohs surgery, showing no recurrences in this study. CD34 immunostaining aids diagnosis but has variable expression patterns.

Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive soft tissue sarcoma.
  • Recurrences are common, typically affecting middle-aged individuals, often on the trunk.
  • CD34 immunostaining aids diagnosis but exhibits variable sensitivity.

Purpose of the Study:

  • To evaluate the efficacy of Mohs surgery for treating DFSP.
  • To analyze clinical and histologic features of DFSP cases.
  • To assess the utility of CD34 immunostaining in DFSP management.

Main Methods:

  • Retrospective review of 16 DFSP cases treated with Mohs surgery (1981-1994).
  • Analysis of clinical and histologic features.
  • Immunohistochemical staining for CD34 performed on one case.

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Main Results:

  • 12 of 16 patients were female; four were under 20.
  • The trunk was the most common tumor location.
  • No recurrences were observed post-Mohs surgery; average 3.3 stages required.
  • CD34 stains were negative on initial biopsy but positive on frozen sections.

Conclusions:

  • DFSP affects all sexes and age groups.
  • Mohs surgery offers improved cure rates and cosmetic outcomes for DFSP.
  • CD34 immunostaining is a valuable adjunct, though variable expression requires careful interpretation.