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Sonic hedgehog regulates patterning in early embryos

V Marigo1, E Laufer, C E Nelson

  • 1Department of Genetics, Harvard Medical School, Boston, USA.

Biochemical Society Symposium
|January 1, 1996
PubMed
Summary
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Sonic hedgehog is a key developmental signal. It works with Fgf-4 to induce Hoxd genes and Bmp-2, crucial for limb anterior-posterior axis patterning.

Area of Science:

  • Developmental Biology
  • Molecular Genetics
  • Embryogenesis

Background:

  • Sonic hedgehog (Shh) is a vertebrate homologue of the Drosophila segment polarity gene hedgehog.
  • Shh is expressed in embryonic inductive centers, suggesting a role in early development.
  • Previous studies implicated Shh in patterning the anterior-posterior axis of limbs.

Purpose of the Study:

  • To investigate the role of Sonic hedgehog in limb patterning.
  • To identify downstream targets and signaling partners of Sonic hedgehog.
  • To elucidate the molecular mechanisms underlying limb anterior-posterior axis formation.

Main Methods:

  • Misexpression of Sonic hedgehog in developing limbs.
  • Analysis of Hoxd gene and Bmp-2 expression.

Related Experiment Videos

  • Investigating the necessity of mesodermal and ectodermal signals.

    • Main Results:

    • Sonic hedgehog misexpression induces Hoxd genes and Bmp-2.
    • Sonic hedgehog alone is insufficient for these inductions.
    • Both Sonic hedgehog (mesoderm) and Fgf-4 (ectoderm) signals are required for Hoxd gene and Bmp-2 induction.

    Conclusions:

    • Sonic hedgehog acts as a crucial signaling molecule in limb development.
    • A coordinated signaling network involving Sonic hedgehog and Fgf-4 patterns the limb anterior-posterior axis.
    • Understanding these signaling pathways is vital for comprehending embryonic development and congenital limb malformations.