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Dissociate arachidonic acid release from eicosanoid synthesis in rat peritoneal macrophages is possible using
J Bourass1, P Boucrot, Y Letourneux
1Laboratoire de Synthèse et d'étude des Substances Naturelles à Activité Biologique, Põle Sciences, La Rochelle, France.
Pharmacological Research
|June 1, 1996
Abstract:
Activated macrophages exposed to the association of eicosapentanoic acid 20:5 n-3 and a synthetic non hydrolysable phospholipid analogue maintained a discrete synthesis of active eicosanoids. 20:4 n-6 split from the internalized 20:4-GPC was accumulated in cells and extracellular fluids. This combination thus represents a novel approach to reduce the 20:4 n-6 cascade.