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Inhibitory effect of caffeic acid phenethyl ester on human leukemia HL-60 cells
1Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers, State University of New Jersey, New Brunswick 08903, USA.
Cancer Letters
|November 29, 1996
Abstract:
Caffeic acid phenethyl ester (CAPE) was synthesized from caffeic acid and phenethyl alcohol (ratio 1:5) at room temperature with dicyclohexyl carbodiimide (DCC) as a condensing reagent. The yield was about 38%. CAPE was found to arrest the growth of human leukemia HL-60 cells. It also inhibits DNA, RNA and protein synthesis in HL-60 cells with IC50 of 1.0 microM, 5.0 microM and 1.5 microM, respectively.