[Antibody formation after filtered blood cell replacement in hematologic-oncologic patients]

We studied the value of leucocyte depletion of platelet and erythrocyte transfusion by filter for the prevention of alloimmunization. In 109 patients with hematological diseases we detected HLA- and platelet specific antibodies by using lymphocytotoxic and IgG-EIA-Thrombomatch. In 17 of the 109 evaluable patients (16%) HLA-antibodies developed (9 female and 8 male). 16 of the 17 had only HLA-antibodies and 1 patient a platelet specific alloantibody primary immunisation. 15 of 17 with a high-risk of prior immunization induced by pregnancy or other transfusions had a 'secondary alloimmunization'.