[Alterations of various parameters of evoked motor potentials in amyotrophic lateral sclerosis]

To assess their interest, we studied different motor evoked potentials (MEP) parameters in 18 amyotrophic lateral sclerosis (ALS) patients and compared them to those obtained in 20 subjects unaffected by neurological diseases: cortical threshold (CT), latency and amplitude of primary responses (PR), central conduction time (CCT), silent period (SP) contralateral to the stimulated cortex and late muscular responses (LMR). In normal subjects MEP parameters were in agreement with those described in the literature, except for LMR. These were only recorded in upper limbs with latencies around 200 ms in 9 out of 20 subjects. In ALS patients, LMR were not modified as compared to normal subjects. Except for mean CCT, in upper and lower limbs, all parameters were altered. We conclude that all MEP parameters are useful in ALS and disclose the involvement of the entire pyramidal tract in this disease.