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THE DECADE OF THE RABiT (2005-15).

G Garty1, H C Turner2, A Salerno3,4

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The Rapid Automated Biodosimetry Tool (RABiT) automated cytogenetics assays for rapid triage after radiological events. Assay development influenced robotics, leading to adaptable systems and a new generation of automated biodosimetry tools.

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Area of Science:

  • Biotechnology
  • Robotics
  • Radiation Biology

Background:

  • Cytogenetics-based biodosimetry is crucial for triage after radiological events.
  • Automation is needed to handle high-throughput sample processing.

Purpose of the Study:

  • To present the historical development of the Rapid Automated Biodosimetry Tool (RABiT) program.
  • To demonstrate the interplay between biological assay development and custom robotic system design.
  • To highlight the transition towards commercially available robotic platforms for biodosimetry.

Main Methods:

  • Development of a custom robotic platform (RABiT) for automating cytogenetics-based biodosimetry assays.
  • Evolution of assays to drive robotic system design.
  • Adaptation of assays for integration with commercial robotic platforms.

Main Results:

  • The RABiT program successfully automated biodosimetry assays from 2005-2015.
  • Assay requirements informed the design of custom robotic solutions.
  • Advances in commercial robotics enabled modifications to assays for 'off-the-shelf' automation.

Conclusions:

  • The development of the RABiT system showcases a successful integration of biological assays and custom robotics.
  • The program paved the way for utilizing commercial robotic platforms in biodosimetry.
  • A second-generation system (RABiT II) is currently being optimized for automated biodosimetry.