[Role of mass transfer processes in drug formulation]

Authors call attention on the possibilities that drug release from solid preparations can be influenced by solubility and dissolution rate according to the clinical requirements regarding the duration of action. The therapeutic time interval may be modulated influencing the rate of absorption by controlling dissolution rate and changing the transport through the membranes. The results obtained from dissolution, absorption and efficacy studies of the evaluated active substances (magnesium oxide, metoprolol, nitrofurantoin) demonstrate the significance of mass transfer processes in the drug formulation.