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Integrins and disease

G S Hillis, A M MacLeod

    Clinical Science (London, England : 1979)
    |December 1, 1996
    PubMed
    Summary
    This summary is machine-generated.

    Cell adhesion molecules, including integrins, are crucial for cell growth, migration, and tissue function. This review focuses on integrins and their significant role in human disease pathogenesis.

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    Area of Science:

    • Cell biology
    • Molecular biology
    • Immunology

    Background:

    • Cell adhesion is fundamental for cellular processes like growth, differentiation, and migration.
    • Interactions between cells and extracellular matrices regulate protein deposition and cellular functions, forming feedback loops.
    • Adhesion molecules, a diverse group of membrane proteins, mediate cell-to-cell, cell-to-matrix, and cell-to-endothelial binding.

    Discussion:

    • Adhesion molecules are classified into four main subfamilies: integrins, selectins, cadherins, and the immunoglobulin superfamily.
    • Integrins are a key family of adhesion receptors involved in numerous cellular signaling pathways.
    • This review specifically examines the critical role of integrins in the development and progression of various human diseases.

    Key Insights:

    Related Experiment Videos

    • Integrins are vital for cell-matrix and cell-cell interactions.
    • Dysregulation of integrin function is implicated in numerous pathological conditions.
    • Understanding integrin roles is essential for developing targeted therapies.

    Outlook:

    • Further research into integrin structure-function relationships will illuminate disease mechanisms.
    • Targeting integrin pathways offers potential therapeutic strategies for human diseases.
    • Investigating integrin involvement in complex diseases remains a key future direction.