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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
09:44

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

Infantile chronic idiopathic intestinal pseudo-obstruction: the role of small intestinal manometry as a diagnostic

J M Fell1, V V Smith, P J Milla

  • 1Department of Gastroenterology, Great Ormond Street Hospital for Children NHS Trust, London.

Gut
|August 1, 1996
PubMed

Insights

Infantile chronic idiopathic intestinal pseudo-obstruction (CIIP) diagnosis is aided by small intestinal manometry. This diagnostic tool helps determine the cause and predict the clinical outcome in infants with CIIP.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Motility Disorders
  • Diagnostic Tools in Medicine

Background:

  • Infantile chronic idiopathic intestinal pseudo-obstruction (CIIP) is a rare, severe condition with varied causes and unpredictable outcomes.
  • Early diagnosis and etiological classification are crucial for managing CIIP in infants.

Observation:

  • Small intestinal manometry was performed on 14 infants diagnosed with CIIP within their first year of life.
  • Histological analysis identified myopathic (n=5), neuropathic (n=4), and unclassified (n=5) etiologies.
  • Fasting phase III activity patterns varied, with low amplitude phase III (motility index < 10 KPa/min) observed in 7 children.

Findings:

  • A motility index < 10 KPa/min correlated with poor outcomes (death or parenteral nutrition dependence) in 7 out of 7 children studied.
  • Children with myopathic histology (n=5) predominantly showed a low motility index (n=4).
  • Small intestinal manometry revealed distinct patterns of motor activity, aiding in etiological differentiation.

Implications:

  • Small intestinal manometry is a valuable tool for diagnosing the etiology of infantile CIIP.
  • Manometry findings can predict the clinical course and long-term outcome in infants with CIIP.
  • This study supports the integration of manometry into the diagnostic workup for suspected infantile CIIP.
Abstract

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