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Related Experiment Videos

Esterified estrogens with and without methyltestosterone decrease arterial LDL metabolism in cynomolgus monkeys

J D Wagner1, L Zhang, J K Williams

  • 1Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, USA. j-wagner@cpm.bgsm.edu

Arteriosclerosis, Thrombosis, and Vascular Biology
|December 1, 1996
PubMed
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Estrogen replacement therapy, with or without androgens, improves arterial LDL metabolism and reduces lipid peroxidation, potentially lowering coronary heart disease risk. These findings suggest beneficial cardiovascular effects extend to combined hormone therapies.

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Lipid Metabolism

Background:

  • Epidemiological and experimental data suggest estrogen replacement therapy (ERT) reduces coronary heart disease (CHD) risk.
  • Mechanisms underlying ERT's cardioprotective effects remain largely unknown.
  • Concerns exist regarding the addition of progestins or androgens to ERT.

Purpose of the Study:

  • To investigate the effects of esterified estrogens alone or combined with an androgen on arterial low-density lipoprotein (LDL) metabolism and early atherogenesis.
  • To assess these effects in ovariectomized female cynomolgus monkeys.

Main Methods:

  • Utilized dual-labeled LDL injected 24 hours before necropsy to assess arterial LDL metabolism.
  • Measured aortic lipid peroxidation products using the thiobarbituric acid reaction.

Related Experiment Videos

  • Analyzed plasma concentrations of apoB-containing lipoproteins and LDL particle size.

    • Main Results:

    • Arterial LDL degradation decreased significantly (64%-84%) in both treatment groups.
    • Aortic cholesteryl ester content decreased by approximately 50% in the thoracic aorta.
    • Reduced aortic lipid peroxidation and improved plasma lipoprotein profiles, including increased total-body LDL catabolism, were observed.

    Conclusions:

    • Decreased arterial LDL metabolism and lipid peroxidation, coupled with improved plasma lipoprotein metabolism, may explain estrogen's protective effects against CHD.
    • Beneficial cardiovascular actions of estrogens appear to extend to combination therapy with androgens.