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[Prevalence and role of anticardiolipin antibodies in Crohn disease]

I Lonjon1, L Beaugerie, A Deschamps

  • 1Service d'Hépato-Gastroentérologie, Hôpital Rothschild, Paris.

Gastroenterologie Clinique Et Biologique
|January 1, 1996
PubMed

Insights

Anticardiolipin antibodies are more prevalent in Crohn's disease patients, but their presence doesn't correlate with disease activity or thrombosis history. This finding impacts understanding of Crohn's disease complications.

Area of Science:

  • Immunology
  • Gastroenterology

Background:

  • Anticardiolipin antibodies (aCL) are associated with antiphospholipid syndrome, endothelial damage, and thrombosis.
  • Crohn's disease (CD) is a chronic inflammatory condition with potential extraintestinal manifestations.

Purpose of the Study:

  • To investigate the frequency of aCL in patients with CD.
  • To determine if aCL presence correlates with clinical disease activity or treatment in CD.

Main Methods:

  • Serum samples from 138 CD patients and 118 controls were tested for IgG aCL.
  • CD patients' history of vascular thrombosis, disease activity, and immunosuppressive therapy (steroids, azathioprine) were assessed.

Main Results:

  • A significantly higher prevalence of aCL was observed in CD patients (11.0%) compared to controls (2.5%; P < 0.02).
  • No correlation was found between aCL positivity and a history of vascular thrombosis in CD patients.
  • aCL presence did not correlate with clinically active intestinal disease (P = 0.77) or current immunosuppressive therapy (P = 0.95).

Conclusions:

  • Patients with Crohn's disease exhibit a significantly higher prevalence of anticardiolipin antibodies.
  • The presence of aCL in CD patients is not associated with a history of vascular thrombosis or current disease activity.
Abstract

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