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Liver enzyme activity and body mass index
C J Burns1, J M Boswell, G W Olsen
1Dow Chemical Company, Midland, Mich. 48674, USA.
Journal of Occupational and Environmental Medicine
|December 1, 1996
Summary
Obesity is linked to higher liver enzyme activity, indicating potential liver injury. Weight gain over time further increased liver enzyme levels in male employees.
Area of Science:
- Occupational Health
- Hepatology
- Biochemistry
Background:
- Obesity is a known risk factor for liver disease.
- Previous studies suggest a link between obesity and liver abnormalities.
- Biochemical liver tests (BLTs) are used to assess liver health.
Purpose of the Study:
- To investigate the association between body mass index (BMI) and liver enzyme activity in male employees.
- To examine the relationship between alcohol consumption and BLTs.
- To assess how weight changes over time impact liver enzyme levels.
Main Methods:
- Analysis of biochemical liver tests (alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase) from two consecutive health surveillance examinations.
- Assessment of body mass index (BMI) and alcohol consumption.
- Statistical analysis controlling for age, race, and alcohol consumption.
Main Results:
- Body mass index (BMI) showed a strong association with increased liver enzyme activity in both examinations.
- Alcohol consumption was also associated with higher BLT results.
- Weight gain over time correlated with a significant increase in alanine aminotransferase activity.
Conclusions:
- Elevated BMI is significantly associated with markers of liver injury, even after controlling for alcohol consumption and other factors.
- Weight gain is a critical factor contributing to increased liver enzyme activity over time.
- These findings highlight the importance of weight management in preventing occupational liver disease.