Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pyoderma gangrenosum severely affecting both hands

D J Adam1, I Nawroz, P W Petrie

  • 1Department of Orthopaedic Surgery, Queen Margaret Hospital Dunfermline, UK.

Journal of Hand Surgery (Edinburgh, Scotland)
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generic health-related quality of life is significantly worse in varicose vein patients with lower limb symptoms independent of CEAP clinical grade.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2012
Same author

Commentary on 'Development of off-the-shelf stent grafts for juxtarenal abdominal aortic aneurysms'.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2012
Same author

Duplex ultrasound outcomes following ultrasound-guided foam sclerotherapy of symptomatic recurrent great saphenous varicose veins.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2011
Same author

Healing and recurrence rates following ultrasound-guided foam sclerotherapy of superficial venous reflux in patients with chronic venous ulceration.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2010
Same author

Duplex ultrasound outcomes following ultrasound-guided foam sclerotherapy of symptomatic primary great saphenous varicose veins.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2010
Same author

The incidence of raised procoagulant factors and hyperhomocysteinaemia in Chinese patients with chronic venous insufficiency.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2010
Same journal

Dorsal (AO/ASIF) pi-plate osteosynthesis in the treatment of distal intraarticular radius fractures.

Journal of hand surgery (Edinburgh, Scotland)·2006
Same journal

Brachial plexus injury in snowboarding.

Journal of hand surgery (Edinburgh, Scotland)·2006
Same journal

Septic arthritis of the small joints of the hand.

Journal of hand surgery (Edinburgh, Scotland)·2006
Same journal

Problematic bone fixation with pyrocarbon implants in proximal interphalangeal joint replacement: short-term results.

Journal of hand surgery (Edinburgh, Scotland)·2006
Same journal

A leiomyoma arising from the deep palmar arterial arch.

Journal of hand surgery (Edinburgh, Scotland)·2006
Same journal

Local anaesthesia for carpal tunnel decompression: a comparison of two techniques.

Journal of hand surgery (Edinburgh, Scotland)·2006
See all related articles

Pyoderma gangrenosum is a rare condition causing hand tissue destruction. Prompt diagnosis and treatment with azathioprine, an immunosuppressant, led to significant improvement.

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis.
  • Hand involvement in PG is exceptionally uncommon and can lead to severe tissue damage.
  • Standard management involves immunosuppression, treating comorbidities, and cautious surgical intervention.

Observation:

  • A patient presented with simultaneous bilateral hand pyoderma gangrenosum.
  • Despite high-dose corticosteroids and controlled ulcerative colitis and rheumatoid arthritis, rapid tissue destruction progressed.
  • Histopathological findings confirmed pyoderma gangrenosum.

Findings:

  • Early diagnosis via biopsy was crucial.
  • Treatment with azathioprine, a cytotoxic immunosuppressant, resulted in dramatic clinical improvement.

Related Experiment Videos

  • This highlights the efficacy of specific immunosuppressive agents in severe cases.

    • Implications:

    • This case underscores the importance of considering PG in hand ulcerative conditions.
    • Aggressive immunosuppressive therapy, such as azathioprine, may be necessary for refractory cases.
    • Timely diagnosis and targeted treatment are vital to prevent extensive tissue loss in rare presentations of pyoderma gangrenosum.