Related Experiment Video
Updated: Oct 6, 2026

Use of a Low-flow Digital Anesthesia System for Mice and Rats
Published on: September 7, 2016
Anaesthesia with the Boyle's bottle vaporizer
Abstract:
Having used the Boyle's bottle vaporizer apparatus out of necessity in a developing country, the concentration of agent that had been administered was investigated retrospectively. Three anaesthetic agents, halothane, isoflurane and enflurane, were measured at different temperatures, using a Boyle's anaesthetic machine and a Boyle's bottle in circuit with a Magill breathing system connected to a Rascal II Agent Monitor. Bubbling a fresh gas flow of 5 l.min-1 through the anaesthetic liquids generated concentrations in excess of 12%. Elevating the initial temperature of the vaporizer increased the delivered concentration, although this effect was short-lived. Therapeutic concentrations of vapour were achieved for all three agents by avoiding bubbling and manipulating the 'splitting ratio' lever. The Boyle's bottle vaporizer may be used with modern anaesthetic agents such as halothane, isoflurane and enflurane. However, the limitations of and variations between vaporizers should be borne in mind. An agent monitor employed at the patient end of the circuit would be an important safety feature.
More Related Videos
Related Concept Videos
Vaporization
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Stages of General Anesthesia
Parenteral Anesthetics: Overview
Inhalational Anesthetics: Overview
Administering Oxygen by Nasal Cannula
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils, connected...

