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Nontypeable Haemophilus influenzae susceptibility: effect of inoculum size and beta-lactamase production
J M Gould1, G J Heidecker, J J LiPuma
1Department of Pediatrics, Allegheny University of Health Sciences, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania 19129, USA.
Abstract:
The activities of cefixime, cefpodoxime, cefprozil, cefuroxime, loracarbef, and amoxicillin/clavulanate against 72 clinical isolates of nontypeable Haemophilus influenzae were determined by using an agar dilution method. The effects of beta-lactamase production and bacterial inoculum size were investigated. All antimicrobials exhibited a significant inoculum effect, demonstrating the importance of accurately determining inoculum size in the performance of antimicrobial susceptibility testing of H. influenzae.
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