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Prenatal diagnosis of ring chromosome 14 after intracytoplasmic sperm injection
1Laboratoire de Biologie de la Reproduction, Centre Hospitalier Universitaire, Nantes, France.
Objective:
To collect extensively abnormal cytogenetic results in pregnancies obtained after intracytoplasmic sperm injection (ICSI).
Design:
Case report.
Setting:
University Hospital of Nantes, France.
Patient(S):
A couple with 5 years of primary infertility and severe male factor undergoing ICSI procedure.
Intervention(S):
Ultrasound-guided transvaginal follicular aspiration, amniocentesis, and medical abortion.
Main Outcome Measure(S):
Serum levels of E2, beta-hCG, and fetal chromosomal karyotype.
Result(S):
Ultrasonic observation at 12 weeks revealed an 8-mm thick cystic hygroma in the nuchal area. Because the karyotypic analysis was [46,XX,r(14)/45,XX,-14], medical abortion was performed at 14 weeks, after the patients gave their informed consent.
Conclusion(S):
According to the prevalence of this unusual chromosomal abnormality in humans, such abnormal cytogenetic results have to be collected extensively to assess the feasibility of using ICSI procedure.