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The prevalence of hemoglobin S and glucose-6-phosphate dehydrogenase deficiency in Jordanian newborn
K Talafih1, A A Hunaiti, N Gharaibeh
1Department of Physiology and Biochemistry, Jordan University of Science and Technology, Irbid, Jordan.
Insights
This study investigated sickle hemoglobin (HbS) and glucose-6-phosphate dehydrogenase (G6PD) deficiency in Jordanian newborns. Results showed G6PD deficiency in 11-12% and HbS carriers in 4-6% of newborns, with a 1% coincidence of both conditions.
Area of Science:
- Genetics
- Hematology
- Public Health
Background:
- Sickle hemoglobin (HbS) and glucose-6-phosphate dehydrogenase (G6PD) deficiency are common inherited red blood cell disorders.
- Understanding their prevalence is crucial for public health planning and resource allocation.
Purpose of the Study:
- To determine the incidence of HbS and G6PD deficiency in Jordanian newborns.
- To provide data for improved healthcare strategies in Jordan.
Main Methods:
- A cohort of 181 newborns was randomly selected at Princess Basma Teaching Hospital.
- Cord blood samples were analyzed for erythrocyte G6PD activity and HbS using hemoglobin electrophoresis.
Main Results:
- G6PD deficiency was observed in 11% of females and 12% of males.
- HbS carrier frequency was 4% in females and 6% in males.
- A 1% coincidence of both G6PD deficiency and HbS was noted; no association with hyperbilirubinemia was found.
Conclusions:
- The study provides essential data on the prevalence of HbS and G6PD deficiency in Jordanian newborns.
- This information can aid in optimizing healthcare resource utilization and planning for genetic disorder management.
Objective:
The aim of this study was to determine the incidence of HbS and glucose-6-phosphate dehydrogenase (G6PD) deficiency in Jordanian newborn.
Study Design:
A total of 181 male and female babies born at Princess Basma Teaching Hospital, randomly selected, and cord blood samples were collected, and the erythrocyte G6PD activity was measured, and the hemoglobin electrophoresis for blood lysate was conducted and scanned for HbS scanning.
Results:
The frequencies of two major red cell genetic defects, sickle hemoglobin (HbS) and deficiency G6PD was determined, of the studied subjects 10 (11%) females and 11 (12%) males were found to be deficient in the G6PD gene. The frequency of HbS carriers among the females was 4% while it was 6% among males. The coincidence of both G6PD deficiency and sickle cell hemoglobin in the samples was 1%. No coincidence was found between G6PD deficiency and hyperbilirubinemia.
Conclusion:
A better understanding of the distributions of these genetic disorders has the potential to aid in the more efficient utilization of health care resources and improved planning.