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Serum interleukin-6 and bone metabolism in patients with thyroid function disorders
P Lakatos1, J Foldes, C Horvath
11st Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
The Journal of Clinical Endocrinology and Metabolism
|January 1, 1997
Summary
Interleukin-6 (IL-6) may contribute to bone loss in hyperthyroidism. Elevated IL-6 levels and production were observed in hyperthyroid women, correlating with reduced bone mineral content.
Area of Science:
- Endocrinology
- Bone Metabolism
- Immunology
Background:
- Hyperthyroidism is associated with increased bone turnover and potential bone loss.
- Interleukin-6 (IL-6) is a cytokine implicated in various physiological and pathological processes, including bone metabolism.
Purpose of the Study:
- To investigate the potential role of IL-6 in mediating bone loss observed in hyperthyroidism.
- To examine the relationship between thyroid status, bone metabolism markers, and IL-6 levels.
Main Methods:
- Serum IL-6 concentrations were measured in female patients with hyperthyroidism and healthy controls.
- IL-6 production by blood mononuclear cells was assessed.
- Bone turnover markers (serum osteocalcin, urinary deoxypyridinoline) and bone mineral content (BMC) were evaluated.
Main Results:
- Hyperthyroid patients exhibited significantly higher serum IL-6 levels compared to controls.
- Increased IL-6 production by mononuclear cells was noted in hyperthyroid women.
- Hyperthyroid subjects showed elevated bone turnover and reduced radius BMC, with the lowest BMC subgroup having the highest IL-6 levels.
Conclusions:
- The findings suggest that IL-6 may play a role in the bone loss associated with hyperthyroidism.
- Elevated IL-6 levels and production in hyperthyroid individuals correlate with markers of increased bone turnover and reduced bone density.