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[Gastric secretion in diabetes]

I Dinkov, K Tsonev, I Nonchev

    Vutreshni Bolesti
    |January 1, 1977
    PubMed
    Summary
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    This study found that diabetes duration, high blood sugar, and insulin treatment significantly reduce gastric secretion in patients. However, overall gastric secretion did not significantly differ from healthy individuals.

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Metabolic Disorders

    Background:

    • Diabetes mellitus can affect various bodily functions, including gastrointestinal motility and secretion.
    • Understanding gastric secretion in diabetic patients is crucial for managing potential complications.

    Purpose of the Study:

    • To investigate gastric secretion in patients with type 2 diabetes mellitus.
    • To assess the impact of diabetes duration, hyperglycemia, and treatment on gastric acid production.

    Main Methods:

    • Maximal gastric acid stimulation using pentagastrin (6 microgram/kg) in 26 diabetic patients.
    • Comparison of gastric secretion indices between diabetic patients and healthy subjects.
    • Analysis of correlations between diabetes parameters (duration, glucose levels, complications, insulin treatment) and gastric secretion.

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    Main Results:

    • No significant overall difference in gastric secretion was observed between diabetic patients and healthy controls.
    • Hypo- and achlorhydria (low or no acid) occurred in 19.2% of patients; hyperchlorhydria (high acid) in 15.4%.
    • Diabetes duration >5 years, hyperglycemia >200 mg%, late degenerative complications, and insulin therapy significantly reduced most gastric secretion indices.

    Conclusions:

    • While overall gastric secretion may not differ, specific subgroups of diabetic patients exhibit altered acid production.
    • Longer diabetes duration, poor glycemic control, and insulin treatment are associated with reduced gastric acid secretion.
    • These findings highlight the impact of diabetes and its management on gastrointestinal function.