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Updated: Aug 7, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
Mechanisms of interference with the MHC class I-restricted pathway of antigen presentation by herpesviruses
1Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland 97201, USA.
Abstract:
Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentation, suggesting that impairment of the cytotoxic T lymphocyte response is necessary for the maintenance of this lifestyle. The diverse molecular mechanisms that have so far been discovered employed by Epstein-Barr virus, herpes simplex viruses, and human and murine cytomegaloviruses are described in this review.
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