Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Analysis program for quantitative detection of chromosome aberrations using comparative genomic hybridization]

K Roth1, G Wolf, M Dietel

  • 1Institut für Pathologie der Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin.

Der Pathologe
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.

The Journal of biological chemistry·1995
Same author

L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides.

Journal of medicinal chemistry·1995
Same author

[In vitro studies of the effect of vasoconstrictor nose drops on ciliary epithelium of human nasal mucosa].

Laryngo- rhino- otologie·1995
Same author

Cyclosporine stimulates expression of transforming growth factor-beta in renal cells. Possible mechanism of cyclosporines antiproliferative effects.

Transplantation·1995
Same author

Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine.

The Journal of biological chemistry·1995
Same author

A regulatory pathway of thermogenesis in brown fat through retinoic acid.

Nutrition reviews·1995

This study introduces an image analysis program for comparative genomic hybridization (CGH) to detect chromosomal imbalances. The new method generates CGH sum karyograms for genotype-phenotype correlation in tumors.

Area of Science:

  • Molecular Cytogenetics
  • Genomics
  • Bioinformatics

Context:

  • Comparative genomic hybridization (CGH) is crucial for detecting chromosomal imbalances in tumors.
  • Existing CGH methods require quantitative and reproducible results for accurate genetic analysis.
  • Tumor characterization often relies on morphological descriptions, necessitating genetic correlation.

Purpose:

  • To develop an image analysis program for quantitative and reproducible CGH analysis.
  • To enable the detection and mapping of genetic alterations in tumor genomes.
  • To correlate tumor genotype with phenotype using CGH sum karyograms.

Summary:

  • A novel image analysis program was developed for comparative genomic hybridization (CGH).
  • This program facilitates the detection and mapping of chromosomal imbalances, generating CGH sum karyograms.

Related Experiment Videos

  • The karyograms document genetic changes as color-coded chromosomes for detailed analysis.

    • Impact:

    • Provides a tool for precise genetic characterization of tumors.
    • Enhances the correlation between genotype and phenotype in cancer research.
    • Supplements traditional morphological tumor descriptions with detailed genetic information.