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Antibiotic resistance: a view from the pharmaceutical industry
1Department of Clinical Research and Development, SmithKline Beecham Pharmaceuticals, Harlow, Essex, England.
Summary
New antibiotic development has reduced disease and death, but rising antibiotic resistance outpaces new drug discovery. Concerted action is crucial to address this growing public health threat.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Antibiotic development has historically reduced morbidity and mortality.
- Increased antibiotic use has led to a rise in antibiotic resistance.
- There has not been a corresponding increase in novel antimicrobial agents with broad-spectrum activity.
Purpose of the Study:
- To highlight the growing disparity between antibiotic resistance and new drug development.
- To emphasize the urgent need for a coordinated response to the antibiotic resistance crisis.
Main Methods:
- This study is a review and analysis of current trends in antibiotic development and resistance.
- It synthesizes data on the efficacy and spectrum of activity of existing and emerging antibiotics.
- It examines the economic and regulatory factors influencing pharmaceutical research and development.
Main Results:
- Significant reductions in morbidity and mortality have been achieved through antibiotic use.
- A notable increase in antibiotic resistance has been observed.
- The pipeline for new antibiotics with improved activity spectrums has not kept pace with resistance.
- Current prospects for addressing antibiotic resistance are concerning without intervention.
Conclusions:
- The current trajectory of antibiotic resistance poses a significant threat to global health.
- A multi-stakeholder approach involving industry, healthcare providers, academia, and governments is essential.
- Urgent, concerted action is required to revitalize antibiotic development and combat resistance.