Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T cell selection and autoimmunity: flexibility and tuning

P S Ohashi1

  • 1Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada. pohashi@oci.utoronto.ca

Current Opinion in Immunology
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting T cell activation in immuno-oncology.

Current oncology (Toronto, Ont.)·2020
Same author

Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

Molecularly targeted therapies in cancer: a guide for the nuclear medicine physician.

European journal of nuclear medicine and molecular imaging·2017
Same author

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

Cell death and differentiation·2015
Same author

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection.

Cell death and differentiation·2014
Same author

IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV.

Cell death and differentiation·2014
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Peptide-MHC interactions are crucial for T cell development and function. Understanding how diverse peptides shape T cell selection impacts tolerance and autoimmunity research.

Area of Science:

  • Immunology
  • Molecular Biology
  • T cell biology

Background:

  • Peptide-Major Histocompatibility Complex (pMHC) interactions are fundamental to adaptive immunity.
  • These interactions dictate T cell repertoire selection in the thymus and influence T cell function in the periphery.

Purpose of the Study:

  • To investigate the impact of varying peptides on T cell selection processes.
  • To explore how different peptide ligands affect mature T cell function.
  • To understand the implications for immune tolerance and the development of autoimmunity.

Main Methods:

  • Utilizing advanced T cell assays.
  • Employing peptide-MHC binding studies.
  • Analyzing T cell repertoire development.

Related Experiment Videos

Main Results:

  • Demonstrated that specific peptide variations significantly alter T cell selection outcomes.
  • Showcased distinct functional profiles of mature T cells responding to different peptides.
  • Identified peptide-dependent mechanisms influencing self-tolerance.

Conclusions:

  • Peptide specificity in pMHC interactions is a key determinant of T cell fate.
  • Modulating peptide presentation offers potential therapeutic strategies for autoimmune diseases.
  • Further research into peptide-MHC dynamics is essential for advancing immunology.