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T cell selection and autoimmunity: flexibility and tuning

P S Ohashi1

  • 1Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada. pohashi@oci.utoronto.ca

Peptide-MHC interactions govern the fate of T cells in the thymus and the peripheral T cell repertoire. Recent progress has involved investigating how different peptides influence T cell selection and mature T cell function and the subsequent implications for tolerance and autoimmunity.

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