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[Ultrastructure of cerebral cortex capillaries in stroke]
Insights
Stroke-induced capillary damage in the cerebral cortex involves cell dystrophy and endothelial hyperplasia. These ultrastructural changes worsen neuronal damage and brain edema due to hypoxia.
Area of Science:
- Neurology
- Pathology
- Cell Biology
Context:
- Electron microscopy of cerebral cortex in stroke patients.
- Focus on dominant hemispheres in 9 deceased individuals.
Purpose:
- To analyze pathological changes in cerebral cortex capillaries post-stroke.
- To identify diffuse, generalizing ultrastructural alterations in brain capillaries.
Summary:
- Capillary wall dystrophy observed, characterized by lysosomal inclusions, lipofuscin granules, mitochondrial disintegration, and altered oxidation-reduction processes.
- Endothelial growth and hyperplasia were noted as key changes.
- These alterations contribute to neuronal damage, exacerbating the stroke's pathological course.
Impact:
- Hypoxia from ischemia plays a crucial role in cerebrovascular disturbances.
- Observed changes lead to plasmorrhagia, brain edema, and further neuronal affection.
- Understanding these ultrastructural changes is vital for stroke research and treatment development.
Abstract:
Analysing the data of electronomicroscopical studies on the dominant hemispheres of the cerebral cortex in 9 patients who died due to strokes, the authors consider the main types of pathological changes in the ultrastructure of capillaries that are of a diffuse generalizing character. They are the following: 1) dystrophy of the capillary wall with the accumulation in it of lysosomal inclusions, lipofuscin granules, with the disintegration of mitochondrias and disturbances of oxidation-reduction processes in the vessel tissues connected with it; 2) the growth and hyperplasia of the endothelium. These changes lead to dystrophic damages of neurons, the maintainance and loading of the course of the main pathological process. Hypoxia, as a result of local ischemia, has an important pathogenetical significance in the disturbances of brain circulation and leads to plasmorrhagia, brain edema and even greater affection of neurons.