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Effect of iomeprol on renal function immediately after abdominal angiography
R Murakami1, H Tajima, T Kumazaki
1Department of Radiology, Nippon Medical School Hospital, Tokyo, Japan.
Acta Radiologica (Stockholm, Sweden : 1987)
|November 1, 1996
Summary
Iomeprol contrast media at 300 and 400 mg I/ml levels induce reversible osmotic diuresis and acute effects on proximal tubular function in patients undergoing abdominal angiography.
Area of Science:
- Radiology
- Nephrology
- Pharmacology
Background:
- Iomeprol is a non-ionic contrast medium used in medical imaging.
- Assessing the renal effects of different osmolality levels of contrast agents is crucial for patient safety.
Purpose of the Study:
- To evaluate the acute renal effects of two osmolality levels of iomeprol.
- To compare the renal impact of iomeprol 300 mg I/ml versus 400 mg I/ml.
Main Methods:
- A double-blind, randomized, parallel-group study.
- Ten patients received iomeprol 300 mg I/ml and ten received iomeprol 400 mg I/ml intraarterially.
- Renal function parameters were monitored post-angiography.
Main Results:
- Urinary volume increased transiently post-angiography.
- No significant decrease in creatinine clearance was observed.
- Increased urinary excretion of sodium and elevated tubular enzymes (N-acetyl-beta-glucosaminidase, gamma-glutamyl transferase) were noted.
- No significant differences between the two iomeprol groups were found.
Conclusions:
- Iomeprol administration induces osmotic diuresis and transient proximal tubular effects.
- These renal changes are reversible.
- Both osmolality levels of iomeprol demonstrated similar acute renal impact.