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Does non-dysenteric intestinal amoebiasis exist?

A C Anand1, P S Reddy, G S Saiprasad

  • 1Department of Medicine, Armed Forces Medical College, Pune, India.

Lancet (London, England)
|January 11, 1997
PubMed
Summary
This summary is machine-generated.

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Chronic bowel symptoms like abdominal pain are not linked to Entamoeba histolytica infection. Most cases are likely irritable bowel syndrome (IBS), suggesting non-dysenteric amoebiasis is rare.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Clinical Diagnostics

Background:

  • Chronic abdominal pain and bowel disturbances affect over 15% of people.
  • Non-dysenteric intestinal amoebiasis and irritable bowel syndrome (IBS) share similar symptoms.
  • The clinical significance of Entamoeba histolytica in these symptoms is unclear.

Purpose of the Study:

  • To assess the clinical significance of Entamoeba histolytica infection in causing chronic bowel symptoms.
  • To differentiate between non-dysenteric intestinal amoebiasis and IBS.

Main Methods:

  • Recruited patients with symptoms suggestive of amoebiasis and symptom-free controls.
  • Performed clinical examination, stool analysis, serology, colonoscopy, and histopathology.
  • Administered a trial of antiamoebic therapy (metronidazole and mebendazole) to symptomatic participants.

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Main Results:

  • No significant differences in E. histolytica prevalence or serological evidence between symptomatic and control groups.
  • Colonoscopic and histopathological abnormalities were similar between groups.
  • A diagnosis of IBS was made in most symptomatic patients; non-dysenteric amoebiasis was diagnosed in only one patient.

Conclusions:

  • Chronic bowel symptoms are not associated with past or present Entamoeba histolytica infection.
  • Most patients presenting with these symptoms likely have IBS.
  • The clinical entity of non-dysenteric intestinal amoebiasis is extremely rare, if it exists.