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The neurochemistry of Alzheimer's disease
1Department of Clinical Neuroscience, University of Göteborg, Mölndal Hospital, Sweden.
Acta Neurologica Scandinavica. Supplementum
|January 1, 1996
Abstract:
The last 15-20 years have seen a wealth of studies to characterize the neurochemical abnormalities of Alzheimer's disease, in particular those involving the beta-amyloid and tau proteins, as well as more recently, apolipoprotein E4. This article provides a summary of the evidence for the involvement of these proteins in Alzheimer's disease pathogenesis based on postmortem brain and CSF studies.