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Related Experiment Videos

Spaced training induces normal long-term memory in CREB mutant mice

J H Kogan1, P W Frankland, J A Blendy

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

Current Biology : CB
|January 1, 1997
PubMed
Summary

Mice lacking CREB proteins show long-term memory deficits, but spaced training can improve their memory. This highlights CREB

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The cAMP responsive element binding protein (CREB) is a transcription factor crucial for long-term memory formation.
  • Studies in various organisms suggest CREB-activated transcription is essential for consolidating memories.
  • CREB's role in memory formation is linked to intracellular cAMP and calcium levels.

Purpose of the Study:

  • To investigate the role of CREB alpha and Delta proteins in long-term memory in mice.
  • To determine if altered training protocols can rescue memory deficits in CREB mutant mice.

Main Methods:

  • Behavioral testing of mice lacking CREB alpha and Delta proteins (CREBalphaDelta-).
  • Assessing memory in tasks such as contextual fear conditioning, spatial learning, and socially transmitted food preferences.

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  • Manipulating intertrial intervals during training to evaluate memory consolidation.

    • Main Results:

    • CREBalphaDelta- mice exhibited significant deficits in long-term memory but not short-term memory.
    • Increasing the intertrial interval during training successfully rescued memory deficits in these mice.
    • The beneficial effect of spaced training was observed across multiple complex behavioral tasks.

    Conclusions:

    • CREB mutant mice display profound long-term memory impairments.
    • CREB function critically influences the training parameters, including the number of trials and intertrial interval, required for memory consolidation.
    • The impact of CREB on memory is evident in both simple conditioning and complex cognitive behaviors.