Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

c-Fos transrepression revisited

M A Cahill1

  • 1Transcriptional Regulation Group, Division of Immunology and Cell Biology, The John Curtin School of Medical Research, Australian National University, Canberra. Mike.Cahill@anu.edu.au

FEBS Letters
|January 2, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Progestogens and membrane-initiated effects on the proliferation of human breast cancer cells.

Climacteric : the journal of the International Menopause Society·2012
Same author

Membrane-initiated effects of progesterone on proliferation and activation of VEGF in breast cancer cells.

Climacteric : the journal of the International Menopause Society·2009
Same author

Differential and quantitative molecular analysis of ischemia complexity reduction by isotopic labeling of proteins using a neural embryonic stem cell model.

Journal of the neurological sciences·2005
Same author

Improved sensitivity proteomics by postharvest alkylation and radioactive labelling of proteins.

Electrophoresis·2000
Same author

MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.

The Journal of biological chemistry·1999
Same author

Antioxidants as well as oxidants activate c-fos via Ras-dependent activation of extracellular-signal-regulated kinase 2 and Elk-1.

European journal of biochemistry·1997
Same journal

Identification of a Shiga toxin A-derived peptide internalized into Gb3 receptor-bearing cells via interaction with the Shiga toxin B subunit.

FEBS letters·2026
Same journal

The dual role of lectins in cancer-immunotherapy tools and therapeutic targets.

FEBS letters·2026
Same journal

Decoding the dynamic extracellular matrix in cancer-3D models and bioscaffolds rewire the rules of tumor progression.

FEBS letters·2026
Same journal

Extending the classical sequence-structure-function paradigm through protein dynamics and context-dependent behavior.

FEBS letters·2026
Same journal

α-Synuclein aggregation landscape from phase separation to neurotoxic intermediates.

FEBS letters·2026
Same journal

Modelling stem cell differentiation related processes-A practical overview for biologists.

FEBS letters·2026
See all related articles

The c-Fos protein, initially thought critical for cell cycle control, may not regulate its own gene expression. Recent findings suggest observed effects are due to experimental artifacts, not a biological feedback loop.

Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Regulation

Background:

  • The c-fos proto-oncogene was identified through viral gene homology.
  • Overexpression of c-Fos protein was linked to deregulated cell growth.
  • Transcriptional transrepression of the c-fos promoter was interpreted as a negative feedback mechanism.

Purpose of the Study:

  • To re-evaluate the role of c-Fos in cell cycle control.
  • To investigate the mechanism behind c-Fos promoter transrepression.

Main Methods:

  • Analysis of c-Fos function and gene regulation.
  • Experimental manipulation of exogenous Fos protein levels.

Main Results:

  • Overexpression of c-Fos protein leads to deregulated growth control.

Related Experiment Videos

  • Transcriptional transrepression of the c-fos promoter is observed.
  • This transrepression is likely due to transcriptional squelching from high exogenous Fos levels.

    • Conclusions:

    • The negative feedback model for c-Fos regulation is improbable.
    • Observed c-Fos transrepression is an artifact of experimental conditions.
    • c-Fos's role in cell cycle control requires re-evaluation.