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Detection of diuretic agents in doping control
1Department de Farmacologia i Toxicologia, Universitat Autonoma de Barcelona, Spain.
Journal of Chromatography. B, Biomedical Applications
|December 6, 1996
Summary
Diuretics are banned in sports. This review covers analytical methods for detecting diuretics in urine, focusing on screening and confirmation techniques essential for doping control. Mass spectrometry is key for confirming results.
Area of Science:
- Analytical Chemistry
- Sports Science
- Forensic Toxicology
Background:
- Diuretics have been banned in sports since 1988.
- Numerous analytical methods have been developed for their detection in urine samples.
- Doping control requires reliable screening and confirmation procedures.
Purpose of the Study:
- To review analytical methodologies for detecting diuretics in sports.
- To focus on methods relevant to doping control, including screening and confirmation.
- To summarize techniques used in chromatographic separation and mass spectrometry.
Main Methods:
- Review of published literature on diuretic analysis.
- Focus on sample preparation and chromatographic separation (liquid and gas chromatography).
- Inclusion of capillary zone electrophoresis and mass spectrometry techniques.
Main Results:
- A comprehensive overview of analytical methods for diuretic detection is presented.
- Screening procedures using chromatography are detailed.
- Mass spectrometry techniques for confirmation are reviewed.
Conclusions:
- Effective analytical methodologies are crucial for enforcing anti-doping regulations.
- The reviewed methods support reliable detection of diuretics in sports.
- Mass spectrometry remains indispensable for confirming diuretic use in athletes.