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Autoantibodies to myeloperoxidase in systemic sclerosis
I C Locke1, J G Worrall, B Leaker
1Department of Rheumatology Research, University College, Royal Free Hospital of Medicine, London, UK.
The Journal of Rheumatology
|January 1, 1997
Summary
Antimyeloperoxidase (MPO) antibodies are not typical in systemic sclerosis (SSc). Their presence in SSc patients may indicate unrelated vasculitis, potentially drug-induced, rather than the autoimmune disease itself.
Area of Science:
- Rheumatology
- Immunology
- Nephrology
Background:
- Antimyeloperoxidase (MPO) antibodies are sensitive markers for vasculitis.
- Their role in autoimmune rheumatic diseases, including systemic sclerosis (SSc), is not fully understood.
- This study investigates the presence and significance of anti-MPO antibodies in SSc patients, particularly concerning renal disease.