Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Macrotestes associated with hyperprolactinemia

R H Ruvalcaba1, M Castro-Magana, M Angulo

  • 1Department of Pediatrics, University of Washington, Tacoma, USA.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First European records of <i>Puccinia modiolae</i> and <i>P. platyspora</i>, two native South American rust fungi, and new observations on their life cycle and morphology.

Mycologia·2024
Same author

Development of pectoral muscle atrophy in critically ill patients.

Medicina intensiva·2022
Same author

Musculoskeletal Tumors in Extremities Diagnosed During the Gestational Period: Case Series and Literature Review.

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2022
Same author

Soft tissue sarcomas in the elbow region and influence of their anatomical features in their treatment. Experience in the Unit of Musculoskeletal Tumours.

Revista espanola de cirugia ortopedica y traumatologia (English ed.)·2020
Same author

Real and spurious hypoxemia in a patient with extreme hyperleukocytosis.

Medicina intensiva·2017
Same author

[Acute total knee replacement infection after a cat bite and scratch: a clinical case and review of the literature].

Revista espanola de cirugia ortopedica y traumatologia·2013
Same journal

Genotype-phenotype associations of <i>MKRN</i>3 variants in children with central precocious puberty: a single-center study from Uzbekistan.

Journal of pediatric endocrinology & metabolism : JPEM·2026
Same journal

Birth prevalence and characterisation of congenital hyperinsulinism in Western Australia over two decades.

Journal of pediatric endocrinology & metabolism : JPEM·2026
Same journal

Erratum to: Reliability of point-of-care glucose in neonates: revisiting hypoglycemia protocols in the NICU.

Journal of pediatric endocrinology & metabolism : JPEM·2026
Same journal

Evaluation of the relationship between HOMA-IR, triglyceride-glucose index, and triglyceride/HDL-cholesterol ratio with the presence and severity of hepatic steatosis in children with obesity.

Journal of pediatric endocrinology & metabolism : JPEM·2026
Same journal

Reflections on GnRH analogues dosage in the context of escape phenomenon: a case report of hypothalamic hamartoma with central precocious puberty and literature review.

Journal of pediatric endocrinology & metabolism : JPEM·2026
Same journal

Steroid profiling in congenital adrenal hyperplasia: comparing immunoassays and LC-MS/MS accuracy.

Journal of pediatric endocrinology & metabolism : JPEM·2026
See all related articles

Prolactin-secreting pituitary macroadenomas in prepubertal boys are rare. Treatment with bromocryptine and growth hormone therapy led to normal stature, sexual maturation, and tumor regression, with unexpected testicular growth observed.

Area of Science:

  • Pediatric Endocrinology
  • Neuroendocrinology
  • Oncology

Background:

  • Prolactin-secreting pituitary adenomas (prolactinomas) are uncommon in prepubertal children, with macroadenomas more prevalent in boys.
  • Short stature and growth deceleration are key indicators for pituitary evaluation in pediatric patients.

Observation:

  • Two prepubertal boys presented with short stature and growth deceleration due to prolactin-secreting pituitary macroadenomas and growth hormone deficiency.
  • Treatment involved bromocryptine and recombinant human growth hormone (hGH) therapy.

Findings:

  • Therapy resulted in normal adult stature, complete sexual maturation, and significant tumor regression.
  • Both patients developed macrotestes, with no other identifiable cause found.

Related Experiment Videos

Implications:

  • Elevated prolactin levels may stimulate testicular growth factors, leading to testicular enlargement (macrotestes) in prepubertal boys.
  • This suggests a novel mechanism of prolactin's influence on testicular development beyond its known effects.
  • Further research is warranted to elucidate the precise mechanisms linking prolactinomas to testicular growth in pediatric males.