Related Experiment Videos
Microcystic meningioma. A case report
1Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea.
Abstract:
Microcystic meningioma is a distinct morphological variant of meningioma, characterized by loose texture and microcysts with formation of large extracellular spaces containing edematous fluid. The tumor cells have stellate and vacuolated cytoplasm with long cytoplasmic processes. We experienced a case of typical microcystic meningioma occurring in the falx cerebri adjacent to the left superior parasagittal sinus in a 41-year-old man. The tumor showed the typical histologic features with a few nests of meningothelial whorls. The tumor cells showed diffuse immunoreactivity for vimentin, epithelial membrane antigen (EMA), and S-100 protein. Ultrastructural study confirmed the meningiomatous nature of the tumor.
Insights
Microcystic meningioma, a rare brain tumor variant, presents with unique cellular structures and fluid-filled spaces. This case report details a typical example found in the falx cerebri, confirming its distinct nature.
Area of Science:
- Neuropathology
- Oncology
Background:
- Meningiomas are tumors arising from the meninges, the membranes surrounding the brain and spinal cord.
- Microcystic meningioma is a recognized morphological subtype with specific histological features.
Observation:
- A case of microcystic meningioma occurred in the falx cerebri of a 41-year-old male patient.
- The tumor exhibited characteristic histological findings, including loose texture, microcysts, and stellate, vacuolated tumor cells with long cytoplasmic processes.
- Nests of meningothelial whorls were also present.
Findings:
- Immunohistochemical analysis revealed diffuse positivity for vimentin, epithelial membrane antigen (EMA), and S-100 protein.
- Ultrastructural examination confirmed the tumor's meningiomatous origin.
Implications:
- This case reinforces the distinct pathological identity of microcystic meningioma.
- Understanding its specific characteristics aids in accurate diagnosis and classification of meningiomas.