Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

What does Mos do in oocytes and somatic cells?

N Sagata1

  • 1Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan. nsagascb@mbox.nc.kyushu-u.ac.jp

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LOCALIZATION AND SEGREGATION OF MATERNAL RNA'S DURING EARLY CLEAVAGE OF XENOPUS LAEVIS EMBRYOS.

Development, growth & differentiation·2023
Same author

Comprehensive behavioural study of GluR4 knockout mice: implication in cognitive function.

Genes, brain, and behavior·2010
Same author

The Mos/MAPK pathway is involved in metaphase II arrest as a cytostatic factor but is neither necessary nor sufficient for initiating oocyte maturation in goldfish.

Development genes and evolution·2001
Same author

Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes.

Developmental biology·2001
Same author

Nek2B, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early Xenopus embryos.

The EMBO journal·2000
Same author

Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes.

Genes & development·2000

Mos protein kinase drives oocyte maturation and cellular transformation by activating MAPK. Its distinct functions stem from different MAPK targets in oocytes versus somatic cells, impacting MPF and c-Fos respectively.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Mos is a protein kinase crucial for vertebrate oocyte meiotic maturation.
  • Ectopic Mos expression induces oncogenic transformation in somatic cells.
  • Mitogen-activated protein kinase (MAPK) is a key mediator of Mos function.

Purpose of the Study:

  • To explore the distinct roles of Mos in oocyte maturation and somatic cell transformation.
  • To elucidate the molecular mechanisms underlying Mos's differential functions.
  • To discuss the cellular basis for Mos's varied activities.

Main Methods:

  • Review of existing literature on Mos function.
  • Analysis of Mos-mediated activation of MAPK pathways.
  • Comparison of Mos targets in oocytes and somatic cells.

Related Experiment Videos

Main Results:

  • Mos activates MAPK in both oocytes and somatic cells, mediating its functions.
  • In oocytes, Mos-MAPK likely stabilizes M-phase promoting factor (MPF).
  • In somatic cells, Mos-MAPK stabilizes c-Fos and induces its gene transcription.

Conclusions:

  • The differential functions of Mos in oocytes and somatic cells are primarily due to distinct MAPK-mediated targets.
  • Understanding these targets provides insight into cell cycle regulation and oncogenesis.
  • Mos represents a critical link between meiotic maturation and cellular transformation pathways.