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Simultaneous formation of peptides and nucleotides from N-phosphothreonine
1Bioorganic Phosphorus Chemistry Laboratory, Tsinghua University, Beijing, P.R. China.
Abstract:
An intramolecular mutual activation between a phosphoryl group and carboxyl group results in the simultaneous formation of nucleotides and peptides by the reaction of nucleosides with N-(O,O-diisopropyl)phosphothreonine in anhydrous pyridine. These results suggest pathways for the simultaneous prebiotic synthesis of peptides and oligonucleotides.