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Peripheral nerve abnormality in multiple sclerosis

M Pollock, C Calder, S Allpress

    Annals of Neurology
    |July 1, 1977
    PubMed
    Summary
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    Peripheral myelin may be affected in multiple sclerosis (MS). This study found reduced myelin thickness in MS sural nerves, suggesting a potential role for peripheral myelin in the disease.

    Area of Science:

    • Neuroscience
    • Neuropathology

    Background:

    • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
    • The involvement of peripheral nerves in MS is not fully understood.

    Purpose of the Study:

    • To investigate the morphometric characteristics of peripheral myelin in patients with multiple sclerosis.
    • To determine if peripheral myelin is affected in MS.

    Main Methods:

    • Sural nerve biopsy specimens from 10 MS patients and age-matched controls were analyzed.
    • Morphometric techniques were used to assess myelin thickness and nerve fiber density.
    • Teased fiber analysis was performed.

    Main Results:

    • Increased frequency of abnormal teased fibers in MS nerves compared to controls.

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  • Many internodes in MS nerves showed at least a 50% reduction in myelin thickness.
  • No significant difference in myelinated nerve fiber densities between MS and control nerves.
  • Regression analysis indicated a generalized reduction of myelin lamellae in MS.

    • Conclusions:

    • Peripheral myelin may be involved in the pathophysiology of multiple sclerosis.
    • Reduced myelin thickness in peripheral nerves suggests a potential role for peripheral demyelination in MS.