Sarcoma of bone

Multiagent chemotherapy and limb salvage surgery are two major advances which have occurred over the last twenty years in the treatment of primary bone sarcoma. Limb salvage as an alternative to amputation results in improved quality of life without a compromise in cure. The complications of limb salvage continue to decrease while the durability of the reconstructions continues to improve. Chemotherapy has dramatically improved long-term survival, particularly in children.