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Althesin (alphadione, CT 1341) a 'new' induction agent for anesthesia
Archivum Chirurgicum Neerlandicum
|January 1, 1977
Summary
Althesin, a steroid hypnotic, was evaluated for anesthesia induction. While comparable to thiopentone, it offered no significant circulatory advantages and carries hypersensitivity risks, leading to its discontinuation.
Area of Science:
- Anesthesiology
- Pharmacology
- Steroid Chemistry
Background:
- Althesin (alphadione) is a hypnotic agent composed of alphaxalone and alphadolone.
- It is formulated as a mixture of two steroids in cremophore EL.
Purpose of the Study:
- To evaluate the efficacy and safety of Althesin for anesthesia induction.
- To determine the dose equivalence of Althesin compared to thiopentone.
- To assess Althesin's impact on circulatory parameters and identify potential side effects.
Main Methods:
- Althesin was administered to 100 patients for anesthesia induction.
- Dose equivalence with thiopentone was established (52 microliter/kg Althesin vs. 3 mg/kg thiopentone).
- Circulatory parameters (pulse, blood pressure, ECG, CVP, etc.) were monitored in a subset of patients.
Main Results:
- Althesin demonstrated comparable efficacy to thiopentone.
- No significant advantages in determined circulatory parameters were observed with Althesin.
- Hypersensitivity reactions were noted as a concern.
Conclusions:
- Althesin is not significantly better or worse than thiopentone regarding circulatory parameters.
- Due to a lack of advantages and reported hypersensitivity reactions, Althesin use was ceased.